Anti-HIV Drug Development Through Computational Methods
نویسندگان
چکیده
منابع مشابه
Anti-hiv Drug Targets
ANTI-HIV DRUG TARGETS HIV is a retrovirus, with a simple structure described in Box 1, and illustrated in Figure 1. It contains genes coding for a number of unique viral enzymes, required at different stages of the virus’s life cycle (see Box 2 and Figure 2). One of these is reverse transcriptase, required to make copies of the viral genes once it has infected human cells. Another is HIV protea...
متن کاملComputational methods in drug discovery
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has mad...
متن کاملComputational methods in drug discovery.
Computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over three decades. These methods are broadly classified as either structure-based or ligand-based methods. Structure-based methods are in principle analogous to high-throughput screening in that both target and ligand structure information is imperative. Str...
متن کاملToward the Development of a Single-Round Infection Assay Based on EGFP Reporting for Anti-HIV-1 Drug Discovery
Background: The rapid increase of HIV-1 strains resistant to current antiretroviral drugs is a challenge for successful AIDS therapy. This necessitates the development of novel drugs, and to this end, availability of screening systems for in vitro drug discovery is a priority. Herein, we report the modification of a previously developed system for increased sensitivity, ease of use, and cost-ef...
متن کاملComputational Methods Aiding Early - Stage Drug Design
This report documents the program and the outcomes of Dagstuhl Seminar 13212 “Computational Methods Aiding Early-Stage Drug Design”. The aim of the seminar was to bring scientists working on various aspects of drug discovery, genomic technologies and computational science (e.g., bioinformatics, chemoinformatics, machine learning, and statistics) together to explore how high dimensional data set...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2014
ISSN: 1550-7416
DOI: 10.1208/s12248-014-9604-9